How genetics and gut bacteria interact in Crohn's disease
The Interplay of Host Genetic Variation and the Gut Microbiome in Crohn's Disease
This study is looking at how your genes and gut bacteria work together in people with Crohn's disease to better understand the condition and find new ways to help manage it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10906658 on NIH RePORTER |
What this research studies
This research investigates the relationship between genetic variations in individuals and their gut microbiome in the context of Crohn's disease, an autoimmune condition that causes chronic inflammation in the digestive tract. By using advanced techniques such as co-culturing intestinal organoids with microbiomes from Crohn's patients, the study aims to observe how these interactions affect gene expression. Additionally, it will analyze existing data to identify genetic factors that influence these changes, potentially leading to new treatment strategies for Crohn's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who are interested in understanding the genetic and microbiome factors affecting their condition.
Not a fit: Patients without a diagnosis of Crohn's disease or those who do not have genetic variations associated with the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with Crohn's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of the gut microbiome in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Nirmalan, Shreya — Wayne State University
- Study coordinator: Nirmalan, Shreya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.