How genetics and gut bacteria interact in Crohn's disease
Official title: The Interplay of Host Genetic Variation and the Gut Microbiome in Crohn's Disease
Funded at Wayne State University · NIH-10906658 · Data updated 2026-11-12
This study is looking at how your genes and gut bacteria work together in people with Crohn's disease to better understand the condition and find new ways to help manage it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | August 17, 2023 |
| Project end | August 16, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,654 |
| NIH project number | 5F30GM151855-02 |
| Project ID | NIH-10906658 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease who are interested in understanding the genetic and microbiome factors affecting their condition.
✕Less likely to help
Patients without a diagnosis of Crohn's disease or those who do not have genetic variations associated with the condition may not benefit from this research.
What this research studies
This research investigates the relationship between genetic variations in individuals and their gut microbiome in the context of Crohn's disease, an autoimmune condition that causes chronic inflammation in the digestive tract. By using advanced techniques such as co-culturing intestinal organoids with microbiomes from Crohn's patients, the study aims to observe how these interactions affect gene expression. Additionally, it will analyze existing data to identify genetic factors that influence these changes, potentially leading to new treatment strategies for Crohn's disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with Crohn's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of the gut microbiome in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Nirmalan, Shreya — Wayne State University
- Study coordinator: Nirmalan, Shreya
Related research
Other NIH-funded projects on the same topics.
-
Site-specific gene-microbial interactions in children with Crohn’s disease
A child-focused study explores how genes and gut microbes interact in very young children with Crohn’s disease to understand why the disease starts and how it might be treated.
-
Ultrasound markers to measure Crohn’s disease activity
A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
-
Understanding abnormal sugar building blocks in Crohn’s disease to guide smarter therapies
This project looks at how a specific genetic variation affects how Crohn’s disease works and whether targeting that pathway could lead to new treatments.
-
AI and single-cell tests to predict Crohn's disease course in children
This project uses artificial intelligence plus single-cell and other molecular data to predict which children and teens with Crohn's disease will have mild versus severe or treatment‑resistant disease.
-
Gut microbes and Parkinson's: how gut chemistry may start harmful protein clumps
A science project looks at how gut bacteria might trigger the harmful clumps of alpha-synuclein in Parkinson's disease, with potential for early interventions.
-
How IL-23 Blockade in Crohn's Disease Changes Immune Cells
This study looks at how the IL-23 blocking therapy risankizumab affects immune cells in people with Crohn’s disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.