How genetic variations in immune system genes affect autoimmune diabetes
Official title: Influence of MHC-II polymorphisms on autoimmune T cell repertoire development and function
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10990216 · Data updated 2026-11-12
This study is looking at how certain genes might affect the immune system's T cells, which can attack the insulin-producing cells in the pancreas and lead to Type 1 diabetes, to help find better ways to diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $530,890 |
| NIH project number | 1R01DK138198-01A1 |
| Project ID | NIH-10990216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of Type 1 diabetes or those who have been identified as at risk for developing the disease.
✕Less likely to help
Patients who do not have any genetic predisposition to Type 1 diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates how specific genetic variations in MHC class II genes influence the development and function of T cells that attack insulin-producing cells in the pancreas, leading to Type 1 diabetes (T1D). By studying a unique mouse model, the researchers aim to understand the mechanisms that make certain individuals more susceptible to T1D while others remain protected. The goal is to uncover new insights that could lead to improved diagnostic methods and treatments for T1D by focusing on the immune response involved in the disease.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and therapeutic strategies for preventing or treating Type 1 diabetes.
How similar studies have gone: Previous research has shown that understanding genetic factors in autoimmune diseases can lead to significant advancements in treatment, suggesting a promising avenue for this study.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Huseby, Eric S — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Huseby, Eric S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.