How genetic factors and sex differences affect flu infection severity
Genetic Contributors to the Impact of Sex on Heterogeneity in Flu Infection
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10866508
This study is looking at how genes and whether someone is male or female can affect how sick kids get from the flu, and it aims to find out why some children have worse symptoms than others.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10866508 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations and sex differences influence the severity of influenza A virus (IAV) infections, particularly in children. By examining gene expression differences between males and females, the study aims to uncover why some individuals experience more severe symptoms than others. The research will utilize advanced techniques to analyze human cells and data from volunteers to identify specific genetic markers that may contribute to these differences. Ultimately, the goal is to enhance our understanding of how sex and genetics interact to affect flu outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-11 years who are at risk for severe influenza infections.
Not a fit: Patients who are older than 11 years or who do not have a history of severe influenza infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies tailored to individual genetic profiles and sex, potentially reducing the severity of flu infections.
How similar studies have performed: Previous research has shown that genetic factors and sex differences can significantly impact disease outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KO, DENNIS CHUN-YONE — DUKE UNIVERSITY
- Study coordinator: KO, DENNIS CHUN-YONE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections, Bacterial Infections