How genetic elements affect genome evolution and health
How transposable elements drive genome evolution through epigenetic mechanisms
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11174935
This study is looking at how certain pieces of DNA that can move around in our genes might affect our health and evolution, especially in relation to inherited diseases and cancers, by changing how our genes are organized and function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11174935 on ClinicalTrials.gov |
What this research studies
This research investigates how transposable elements (TEs), which are segments of DNA that can move around within the genome, influence genome evolution and health through epigenetic mechanisms. It focuses on understanding the detrimental effects of TEs, including their role in inherited disorders and cancers, by examining how they modify chromatin and alter the three-dimensional structure of the genome. By studying these processes, the research aims to uncover the evolutionary forces driving TE variation and their impact on gene function and overall host health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of genetic disorders or cancers linked to transposable elements.
Not a fit: Patients with conditions unrelated to genetic variations or transposable elements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of certain cancers and inherited disorders, potentially informing future treatments or preventive strategies.
How similar studies have performed: Previous research has shown promising results in understanding the role of transposable elements in genetic disorders, indicating that this approach has potential for significant findings.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, GRACE YUH CHWEN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: LEE, GRACE YUH CHWEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancers, Colon Cancer, Disease