How Genes Linked to Brain Development Disorders Affect Brain Wiring
Neurodevelopmental Disorder Risk Gene Regulation of Intrinsic Membrane Excitability: A Rheostat that Tunes Dendritic Morphogenesis to Regulate Circuit Assembly During Development
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11140431
This project aims to understand how specific genes guide the formation of brain connections during development, which is important for thinking and behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11140431 on ClinicalTrials.gov |
What this research studies
This project explores how genes associated with neurodevelopmental disorders (NDDs) influence the way brain circuits are built during early life. We know that problems with these brain connections can lead to cognitive difficulties seen in NDDs. Researchers want to discover how these specific genes work at a cellular level to ensure proper brain wiring. By understanding these basic processes, we hope to learn why some children develop NDDs and how their brains might be different. This knowledge could eventually lead to new ways to support healthy brain development.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but it focuses on understanding the genetic basis of neurodevelopmental disorders.
Not a fit: Patients seeking immediate therapeutic interventions would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into the causes of neurodevelopmental disorders, paving the way for future treatments or interventions.
How similar studies have performed: This project builds upon the recent discovery that single gene changes can cause neurodevelopmental disorders, exploring a novel hypothesis about how these genes function.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUMBAUGH, GAVIN R — UNIVERSITY OF FLORIDA
- Study coordinator: RUMBAUGH, GAVIN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Candidate Disease Gene