How genes influence inflammation during tissue repair and vascular diseases
Official title: The epigenetic regulation of inflammation in tissue repair and vascular disease
Funded at University of Michigan at Ann Arbor · NIH-10843045 · Data updated 2026-11-12
This study is looking at how changes in our genes can influence inflammation during healing and diseases like abdominal aortic aneurysms and COVID-19, with the goal of finding new ways to help improve treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2030 |
| Funding year | 2024 |
| Award (this year) | $1,053,460 |
| NIH project number | 5R35HL167143-02 |
| Project ID | NIH-10843045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with abdominal aortic aneurysms, cardiovascular diseases, or those recovering from COVID-19.
✕Less likely to help
Patients with acute inflammatory conditions unrelated to chronic inflammation or vascular diseases may not benefit from this research.
What this research studies
This research investigates the role of epigenetics in regulating inflammation related to tissue repair and vascular diseases. It focuses on understanding how changes in gene expression affect immune responses, particularly in conditions like abdominal aortic aneurysms and COVID-19. The research utilizes animal models and patient-derived cells to explore mechanisms of inflammation and identify potential therapeutic targets. By studying how immune cells behave during tissue repair, the research aims to uncover new biomarkers and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic inflammation and vascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetics in inflammation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Gallagher, Katherine Ann — University of Michigan at Ann Arbor
- Study coordinator: Gallagher, Katherine Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.