How gasdermin proteins are controlled by enzyme cuts and chemical tags
Regulation of gasdermins through protease processing and other post-translational modifications.
['FUNDING_OTHER'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11249115
Researchers are learning how gasdermin proteins are switched on or off by enzyme cuts and chemical tags to help people with autoimmune and inflammatory conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11249115 on ClinicalTrials.gov |
What this research studies
This project looks at gasdermin proteins, which can trigger a fiery form of cell death that drives inflammation in infections and autoimmune diseases. The team uses biochemical and structural experiments plus cell-based tests to see how proteases (enzyme cuts) and other chemical tags like ubiquitin change gasdermin activity. They will map which enzymes turn gasdermins on or off and how other post-translational changes affect cell death. That information could point to new ways to prevent harmful inflammation or create drugs that block damaging gasdermin activity.
Who could benefit from this research
Good fit: People with autoimmune or autoinflammatory conditions, or those willing to donate blood or tissue samples for research, would be the most relevant participants.
Not a fit: People without inflammatory or autoimmune conditions or those seeking immediate treatment changes are unlikely to benefit directly from this basic science work.
Why it matters
Potential benefit: If successful, this work could point to new treatments that reduce damaging inflammation in autoimmune or autoinflammatory diseases.
How similar studies have performed: Prior studies have shown gasdermins drive inflammatory cell death, but the specific roles of other proteases and chemical modifications are still largely unproven.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAO, TSAN SAM — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: XIAO, TSAN SAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases