How fat tissue affects heart changes during stress
Official title: Adipose tissue mediates cardiac metabolic remodeling in the pathologically stressed heart in the absence of primary metabolic stress
Funded at Ohio State University · NIH-11049190 · Data updated 2026-11-12
This study is looking at how fat tissue around the heart affects its ability to handle stress, especially during heart failure, to help find new ways to understand and treat heart disease, even in people who don’t have diabetes or obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $707,005 |
| NIH project number | 5R01HL164290-03 |
| Project ID | NIH-11049190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing heart failure or related cardiac conditions, regardless of their metabolic health.
✕Less likely to help
Patients with isolated metabolic disorders without any cardiac involvement may not benefit from this research.
What this research studies
This research investigates the role of adipose tissue in the heart's response to stress, particularly how it influences metabolic changes in the heart during conditions like heart failure. The study will explore how fat tissue reacts to stress on the heart, even in the absence of other metabolic issues like diabetes or obesity. By examining the interactions between heart function and fat tissue, researchers aim to uncover new insights into heart disease mechanisms and potential treatment targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating heart failure by targeting adipose tissue interactions.
How similar studies have gone: While the specific focus on adipose tissue's role in cardiac stress is relatively novel, similar studies have shown promising results in understanding metabolic interactions in heart disease.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Lewandowski, E Douglas — Ohio State University
- Study coordinator: Lewandowski, E Douglas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.