How exposure to certain chemicals affects heart disease development
Official title: Exposure to PFAS mixture induces atherosclerosis via modulation of bile acid transport
Funded at Wayne State University · NIH-10897736 · Data updated 2026-11-12
This study is looking at how everyday chemicals called PFAS might affect heart health by influencing cholesterol and bile acids, and it's designed for anyone interested in understanding the risks these substances could pose for developing heart problems like atherosclerosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $78,892 |
| NIH project number | 5F32ES034638-02 |
| Project ID | NIH-10897736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of exposure to PFAS or those at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not have a history of PFAS exposure or existing cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates the impact of per- and polyfluoroalkyl substances (PFAS), commonly found in everyday products, on the development of atherosclerosis, a condition that can lead to heart attacks and strokes. The study focuses on understanding how PFAS exposure influences cholesterol levels and bile acid transport in the body, using animal models to simulate human responses. By examining these mechanisms, the research aims to uncover the potential risks associated with PFAS exposure and its role in cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for heart disease linked to environmental chemical exposure.
How similar studies have gone: While there is ongoing research into the health effects of PFAS, this specific investigation into its role in atherosclerosis is novel and has not been extensively studied.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Roth, Katherine — Wayne State University
- Study coordinator: Roth, Katherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.