How exercise affects energy sensors in muscle cells
mitoAMPK in exercise benefits
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-10840882
This study is looking at how regular exercise helps a special protein in your muscles that keeps your energy levels up and your cells healthy, especially for people with metabolic issues like diabetes, to see how it can help prevent chronic diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-10840882 on ClinicalTrials.gov |
What this research studies
This research investigates how regular exercise influences a specific protein complex called mitoAMPK in muscle cells, which plays a crucial role in energy management and mitochondrial health. The study aims to understand how mitoAMPK is activated during exercise and its role in removing damaged mitochondria, a process essential for maintaining muscle function and overall metabolic health. By examining the mechanisms behind these processes, the research seeks to uncover new insights into how exercise can prevent chronic diseases, particularly in individuals with metabolic disorders like diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old, particularly those with metabolic conditions such as diabetes.
Not a fit: Patients who are not adults or those without metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise recommendations and therapies for patients with metabolic disorders, enhancing their health and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of AMPK in metabolic health, indicating that this approach has potential for significant findings.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAN, ZHEN — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: YAN, ZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: chronic disorder, Chronic Disease