How errors in chromosome division lead to cancer
Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11178675
This research looks at why chromosomes sometimes split unevenly and how those mistakes can drive cancers, aiming to point to new treatment targets for people with tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11178675 on ClinicalTrials.gov |
What this research studies
From my point of view, the team studies how chromosomes get misdivided during cell division and how that creates abnormal chromosome patterns seen in many cancers. They focus on events like chromothripsis (chromosomes breaking and being stitched back together) and on proteins such as TRIP13 that help control the chromosome-segregation checkpoint. The work uses molecular and cell biology experiments, genomic analyses, and laboratory models to map the steps that lead from a division error to tumor growth. This is laboratory-based research at UC San Diego aimed at uncovering biological processes that could be targeted by future therapies.
Who could benefit from this research
Good fit: This is not a clinical trial enrolling patients for treatment, though researchers may ask cancer patients to donate tumor tissue or data for laboratory studies.
Not a fit: Patients seeking immediate treatment or an active clinical trial are unlikely to benefit directly from this basic laboratory research right now.
Why it matters
Potential benefit: If successful, the findings could identify new targets for drugs that prevent or slow cancer driven by chromosome errors.
How similar studies have performed: Basic research on chromosome instability has already clarified cancer drivers and led to therapeutic ideas, but this specific focus on TRIP13 and chromothripsis remains largely exploratory.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLEVELAND, DON W — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CLEVELAND, DON W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer, Cancers