How environmental pollutants affect skin cancer risk from UV exposure
Official title: Mechanisms of augmented UVB immunosuppressive responses by polyaromatic hydrocarbons
Funded at Wright State University · NIH-10940266 · Data updated 2026-11-12
This study is looking at how sunlight and certain pollutants in the environment can work together to increase the risk of skin cancer, helping us understand how these factors affect your skin's immune system and overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $20,315 |
| NIH project number | 3R21ES033806-02S1 |
| Project ID | NIH-10940266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of skin cancer or those frequently exposed to UV radiation and environmental pollutants.
✕Less likely to help
Patients who do not have a history of skin cancer or are not exposed to significant levels of UV radiation or environmental pollutants may not benefit from this research.
What this research studies
This research investigates how exposure to ultraviolet radiation (UVR) and environmental pollutants, specifically polycyclic aromatic hydrocarbons (PAHs), interact to influence skin cancer development. The study focuses on understanding the mechanisms behind immunosuppression and carcinogenic effects caused by these combined exposures. By examining the role of microvesicle particles released from skin cells in response to UVR, the research aims to uncover new insights into the pathophysiology of skin cancer. Patients may benefit from a better understanding of how environmental factors contribute to their risk of skin cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for skin cancer by identifying key environmental risk factors.
How similar studies have gone: Previous research has shown promising results in understanding the effects of environmental pollutants on skin health, indicating that this approach may yield valuable insights.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Sahu, Ravi Prakash — Wright State University
- Study coordinator: Sahu, Ravi Prakash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.