How environmental pollutants affect skin cancer responses to UV radiation
Mechanisms of augmented UVB immunosuppressive responses by polyaromatic hydrocarbons
This study is looking at how sunlight and certain pollutants in the environment can affect your skin health and increase the risk of skin cancer, helping us understand how these factors work together in your body.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project ID | NIH-10688121 on NIH RePORTER |
What this research studies
This research investigates how exposure to ultraviolet radiation (UVR) and environmental pollutants, specifically polycyclic aromatic hydrocarbons (PAHs), interact to influence skin health and cancer development. The study focuses on understanding the mechanisms by which UVR can suppress the immune response and contribute to skin cancer, particularly through the release of signaling molecules from skin cells. By examining the effects of these stressors on skin cells and their systemic implications, the research aims to uncover new insights into the relationship between environmental factors and skin cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of skin cancer or those frequently exposed to UV radiation and environmental pollutants.
Not a fit: Patients who have no history of skin exposure or those living in areas with minimal environmental pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating skin cancer by understanding how environmental factors contribute to disease.
How similar studies have performed: While the interaction between UVR and environmental pollutants is a relatively novel area of research, previous studies have shown promising results in understanding the effects of individual stressors on skin health.
Where this research is happening
Dayton, United States
- Wright State University — Dayton, United States (Active)
Researchers
- Principal investigator: Sahu, Ravi Prakash — Wright State University
- Study coordinator: Sahu, Ravi Prakash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.