How endothelial cells maintain stability in blood vessels
miRNA-regulation at focal adhesions establishes vascular mechanohomeostasis
This study looks at how the cells that line our blood vessels react to changes in blood flow and the stiffness of nearby tissues, focusing on tiny molecules called microRNAs that help these cells stick together and communicate, which could help us learn more about keeping our blood vessels healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10656557 on NIH RePORTER |
What this research studies
This research investigates how endothelial cells, which line blood vessels, respond to mechanical changes in their environment, such as blood flow and stiffness of surrounding tissues. By focusing on the role of microRNAs in regulating cell adhesion and communication, the study aims to understand how these cells maintain their structural integrity and function under varying conditions. The researchers will use both laboratory techniques and in vivo models to explore these mechanisms, which could lead to new insights into vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases or conditions affecting blood vessel function.
Not a fit: Patients with non-cardiovascular related health issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cardiovascular diseases by enhancing our understanding of vascular stability.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in vascular health, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Nicoli, Stefania — Yale University
- Study coordinator: Nicoli, Stefania
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.