How endothelial cells affect T cells in lung injuries caused by influenza
Endothelial antigen presentation to T cells as a pathogenic mechanism in influenza-induced acute lung injury
This study is looking at how certain cells in the lungs react during flu infections and how this can cause serious breathing problems, with the goal of finding new ways to help people who get really sick from the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11037964 on NIH RePORTER |
What this research studies
This research investigates how endothelial cells in the lungs present antigens to T cells during influenza infections, which can lead to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). The study aims to understand the mechanisms behind endothelial cell injury and inflammation triggered by the influenza virus. By identifying the different types of endothelial cells and their roles, the research seeks to uncover potential therapeutic targets to prevent or treat ALI/ARDS. This could lead to new strategies for managing severe respiratory complications in patients with influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients with influenza who are at risk of developing acute lung injury or ARDS.
Not a fit: Patients with lung injuries not related to influenza or those with chronic lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that significantly reduce mortality and improve recovery for patients suffering from influenza-induced lung injuries.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial cells in lung injury, but this specific approach is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Zhang, Lianghui — University of Pittsburgh at Pittsburgh
- Study coordinator: Zhang, Lianghui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.