How early microbial exposure affects immune system development
Biasing immunological development with early life microbial colonization
['FUNDING_R15'] · UNIVERSITY OF MASSACHUSETTS BOSTON · NIH-10730933
This study is looking at how the germs we encounter early in life can shape our immune system and overall health later on, using African Clawed Frogs to help us understand how this works, which might eventually help people with autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10730933 on ClinicalTrials.gov |
What this research studies
This research investigates how the timing and type of microbial exposure during early development can influence the immune system's functioning and health outcomes later in life. Using the African Clawed Frog as a model, the study aims to understand how early life microbial colonization can either promote or suppress immune responses. By examining the effects of specific microbial encounters, researchers hope to uncover critical windows for immune education that could inform future treatments for autoimmune diseases. The findings may provide insights into how similar mechanisms operate in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who may be at risk for autoimmune conditions.
Not a fit: Patients with established autoimmune diseases or those over 21 years old may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating autoimmune diseases by understanding how early microbial exposure shapes immune responses.
How similar studies have performed: Other research has shown promising results in understanding immune system development through microbial exposure, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODHAMS, DOUGLAS C — UNIVERSITY OF MASSACHUSETTS BOSTON
- Study coordinator: WOODHAMS, DOUGLAS C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease