How early lung transplant injury affects long-term transplant health
The Clinical and Molecular Impacts of Lung Primary Graft Dysfunction
This project looks at how severe early lung injury after transplant affects rejection, infections, and lung function in people who have had lung transplants.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11177616 on NIH RePORTER |
What this research studies
You would be followed during the first year after your lung transplant at one of three hospitals in the consortium. The team will collect airway brush samples at three time points and use RNA sequencing to see which genes and pathways are active in the airways. Researchers aim to link severe primary graft dysfunction (early post-transplant lung injury) with later rejection, bacterial infections, and changes in lung function. The work combines clinical data and molecular testing to find signals that could explain why some people do worse after transplant.
Who could benefit from this research
Good fit: Adults who have recently received a lung transplant and are followed at one of the participating centers (University of Pittsburgh, UCSF, or Johns Hopkins), especially those who experience early post-transplant lung injury, are ideal candidates.
Not a fit: People who are not lung transplant recipients or who cannot attend a participating center for airway sampling and follow-up are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help doctors identify transplant recipients at higher risk for chronic rejection and point to new ways to prevent infections and preserve lung function.
How similar studies have performed: Previous clinical studies have linked severe early graft dysfunction to later chronic rejection, but using airway RNA profiling over the first year to map the molecular steps is a newer approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Mcdyer, John F — University of Pittsburgh at Pittsburgh
- Study coordinator: Mcdyer, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.