How early life challenges affect future stress responses
Epigenetic priming of response to future stressors
['FUNDING_R01'] · PRINCETON UNIVERSITY · NIH-11010852
This study looks at how tough experiences early in life can affect the brain's reaction to stress as we grow up, using mice to learn more about the changes that might make some people more likely to feel anxious or depressed later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11010852 on ClinicalTrials.gov |
What this research studies
This research investigates how early life adversity influences the brain's response to stress later in life. By studying a mouse model, the researchers aim to understand the neurobiological changes that occur due to early stress and how these changes can lead to increased vulnerability to anxiety and depression. The study focuses on the ventral tegmental area of the brain, examining how early experiences can alter gene expression through epigenetic mechanisms. This could help identify biological markers for those at risk of developing stress-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant stress or adversity during childhood and are at risk for anxiety or depression.
Not a fit: Patients who have not experienced early life adversity or those with unrelated psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating anxiety and depression in individuals who have experienced early life adversity.
How similar studies have performed: Previous research has shown that understanding the neurobiological basis of stress sensitivity can lead to significant advancements in mental health treatment, indicating that this approach has potential for success.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENA, CATHERINE JENSEN — PRINCETON UNIVERSITY
- Study coordinator: PENA, CATHERINE JENSEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders, Anxiety Disorders