How early life challenges affect brain signaling and behavior
The Impact of Early Life Adversity on mGluR5-driven Endocannabinoid Signaling and Behavioral Adaptability
This study looks at how tough experiences in childhood can affect the brain and behavior as we grow up, especially in relation to anxiety and depression, and it uses animal models to find ways to help people who have gone through these challenges.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10996963 on NIH RePORTER |
What this research studies
This research investigates how experiences of adversity during early life can influence brain signaling pathways and behavioral adaptability later in life. By examining the role of mGluR5-driven endocannabinoid signaling, the study aims to understand the neurobiological mechanisms that link early life stress to neuropsychiatric disorders such as anxiety and depression. The research utilizes animal models to explore changes in brain function and behavior resulting from early life adversity, providing insights into potential therapeutic targets for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant adversity during their early life and are currently facing neuropsychiatric challenges.
Not a fit: Patients who have not experienced early life adversity or do not exhibit neuropsychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neuropsychiatric disorders linked to early life adversity.
How similar studies have performed: Previous research has shown promising results in understanding the impact of early life adversity on brain function and behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: De Carvalho, Gregory — University of California-Irvine
- Study coordinator: De Carvalho, Gregory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.