How early brain activity and parenting affect childhood anxiety risk

Precursors of Anxiety: The Role of Lateralized Brain Activation and Maternal Sensitivity

NIH-funded research Washington State University · NIH-11247596

This work looks at whether infants' brain activity patterns together with mothers' sensitive caregiving relate to early fearful behavior and later anxiety risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWashington State University NIH-funded
Lab location1 site (Pullman, United States)
Project IDNIH-11247596 on NIH RePORTER

What this research studies

From a parent's viewpoint, researchers follow infants through the first year(s) to watch how early fearful reactions and brain signals change over time. Babies will wear simple EEG caps so scientists can measure left-right frontal brain activity while their behavior is observed. Mothers will answer questions and take part in tasks that show how they interact sensitively with their infant. The team will link patterns of brain changes and infant fearfulness with caregiving quality to see which combinations predict higher anxiety risk later.

Who could benefit from this research

Good fit: Ideal candidates are infants in their first year and their primary caregivers who can attend lab visits for EEG and behavioral visits.

Not a fit: Adults with established anxiety or families unable to complete infant lab visits or EEG measurements are unlikely to benefit directly from participating.

Why it matters

Potential benefit: If successful, this work could help identify infants at higher risk for anxiety earlier and point to parenting-based supports to reduce that risk.

How similar studies have performed: Previous studies have linked infant fearful temperament and right-frontal EEG patterns with later anxiety, but examining how left-right brain changes unfold across infancy with maternal sensitivity as a moderator is relatively new.

Where this research is happening

Pullman, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Anxiety Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.