How drug interactions affect kidney health in hospitalized patients
Drug-drug interactions and kidney disease in hospitalized patients
This study is looking at how certain antibiotics might affect people with kidney disease while they're in the hospital, especially if these medications could lead to more kidney problems, and it aims to help make medications safer for kidney patients in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10986978 on NIH RePORTER |
What this research studies
This research investigates the effects of drug-drug interactions (DDIs) on patients with kidney disease, particularly those hospitalized. It aims to understand how commonly used antibiotics may increase the risk of acute kidney injury and chronic kidney disease. The study will also explore how changes in kidney function can affect the severity of these drug interactions. By training researchers in advanced methods, the project seeks to improve the safety of medications for kidney patients and lay the groundwork for future studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients who have acute or chronic kidney disease and are receiving multiple medications.
Not a fit: Patients who are not hospitalized or do not have kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer medication practices for patients with kidney disease, reducing the risk of harmful drug interactions.
How similar studies have performed: Previous research has indicated that understanding drug interactions in patients with kidney disease can lead to significant improvements in patient safety, suggesting that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Miano, Todd Anthony — University of Pennsylvania
- Study coordinator: Miano, Todd Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.