How different types of mitochondria in brain cells affect learning and memory.
Mitochondrial diversity as a regulator of cell- and circuit-specific functions
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-10892057
This study is looking at how special parts of brain cells called mitochondria in a region important for social memory might help those cells learn and process information better, which could help us understand brain health and disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-10892057 on ClinicalTrials.gov |
What this research studies
This research investigates the unique properties of mitochondria in specific neurons of the hippocampus, particularly in the CA2 region, which is important for social memory. By using advanced techniques, the study aims to understand how these distinct mitochondria influence the neurons' ability to process information and contribute to learning. The researchers will explore how mitochondrial calcium uptake and energy production affect the function of these neurons and their connections in the brain. This work could provide insights into the role of mitochondrial diversity in brain health and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder (ASD) who may experience challenges with learning and memory.
Not a fit: Patients with conditions unrelated to mitochondrial function or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving learning and memory in individuals with conditions like autism.
How similar studies have performed: While the specific focus on mitochondrial diversity in CA2 neurons is relatively novel, related research has shown promising results in understanding mitochondrial roles in brain function.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FARRIS, SHANNON — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: FARRIS, SHANNON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder, Brain Diseases, Brain Disorders