How different NRAS mutations affect cancer development
Official title: Molecular mechanisms of allele-specific NRAS signaling and tumorigenesis
Funded at Ohio State University · NIH-10980720 · Data updated 2026-11-12
This study is looking at how different changes in the NRAS gene affect cancer, especially in people with acute myeloid leukemia and melanoma, to help understand why some patients respond better to treatments than others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $640,969 |
| NIH project number | 1R01CA287193-01A1 |
| Project ID | NIH-10980720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or melanoma who have specific NRAS mutations.
✕Less likely to help
Patients without NRAS mutations or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the specific ways in which different mutations of the NRAS gene contribute to cancer, particularly focusing on acute myeloid leukemia and melanoma. By studying various NRAS mutations in mouse models, the researchers aim to understand how these mutations influence cancer progression and response to treatment. The approach involves examining the biochemical properties of NRAS mutants and their interactions with other proteins involved in cell signaling. This could lead to insights into why certain patients respond differently to therapies based on their specific NRAS mutations.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with acute myeloid leukemia and melanoma based on their specific NRAS mutations.
How similar studies have gone: Previous research has shown that understanding specific mutations in cancer genes can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Burd, Christin E — Ohio State University
- Study coordinator: Burd, Christin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.