How different ACL surgeries affect knee muscle control

Neuromuscular response to competing ACL surgeries

NIH-funded research Rhode Island Hospital · NIH-11282935

This project compares whether a newer ligament-healing approach called BEAR helps people with ACL tears keep more normal muscle use and knee movement than standard ACL reconstruction.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRhode Island Hospital NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-11282935 on NIH RePORTER

What this research studies

If you join, you'll be one of the BEAR-MOON Trial participants whose knee function is monitored after either BEAR or standard ACL reconstruction. The team will record how your thigh and leg muscles activate during movements like hopping and will measure knee motion with motion-capture tests. They will use machine learning to analyze muscle activation and movement data to see if BEAR preserves more normal neuromuscular patterns than reconstruction. The project adds a second site in Minnesota to include more patients and strengthen the results.

Who could benefit from this research

Good fit: Ideal candidates are people with a recent ACL tear who are enrolled in the BEAR-MOON Trial at a participating center.

Not a fit: People who are not eligible for the BEAR-MOON Trial, have chronic or partial ACL injuries not treated by these procedures, or who cannot attend participating sites may not benefit from participation.

Why it matters

Potential benefit: If successful, this work could help surgeons choose an operation that better preserves muscle control and may improve long-term knee function after ACL tear.

How similar studies have performed: Early clinical studies report that BEAR restored muscle strength at two-year follow-up more than ACL reconstruction, while applying machine learning to link neuromuscular patterns to movement is a newer approach.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions ACL injury
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.