How differences in genome structure affect immune responses
Official title: Genome organization, evolutionary structural variation, and gene regulation in immunity
Funded at University of Chicago · NIH-10994617 · Data updated 2026-11-12
This study looks at how differences in the genetic makeup of mice and humans affect how our immune systems work, with the hope of finding better ways to treat diseases related to immune problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 4, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $558,512 |
| NIH project number | 5R01AI172067-04 |
| Project ID | NIH-10994617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those interested in understanding their immune responses better.
✕Less likely to help
Patients with stable immune conditions or those not affected by immune system variations may not receive direct benefits from this research.
What this research studies
This research investigates how variations in the structure of genomes between species, particularly between mice and humans, influence the regulation of immune responses. By examining structural changes such as translocations and gene relocations, the study aims to understand how these alterations affect the function of immune cells. The goal is to improve our understanding of immune regulation, which could lead to better treatments for diseases that involve immune dysfunction. Patients may benefit from insights gained about how their immune systems respond to various pathogens.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, particularly those with immune-related conditions.
How similar studies have gone: Previous research has shown that understanding structural variations in genomes can lead to significant advancements in immunology, indicating that this approach has potential for success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Weinmann, Amy Susan — University of Chicago
- Study coordinator: Weinmann, Amy Susan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.