How communication between the brain and fat tissue affects aging and longevity
Official title: The intertissue communication between the hypothalamus and adipose tissue for mammalian aging and longevity control
Funded at Washington University · NIH-11092782 · Data updated 2026-11-12
This study looks at how a part of your brain talks to fat tissue and how that affects aging, focusing on a special enzyme that helps keep your cells healthy; the goal is to find ways to help you age better and stay healthier as you get older.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $597,195 |
| NIH project number | 5U01AG086196-02 |
| Project ID | NIH-11092782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include older adults experiencing age-related physiological decline.
✕Less likely to help
Patients with acute or severe age-related diseases that are not primarily linked to metabolic or cellular aging may not receive benefit from this research.
What this research studies
This research investigates the communication between the hypothalamus and adipose tissue, focusing on how this interaction influences aging and longevity in mammals. The study examines the role of a specific enzyme, eNAMPT, which is involved in the production of NAD+, a crucial molecule for cellular function. By exploring how this communication changes with age, the research aims to identify mechanisms that could potentially counteract age-related decline. Patients may benefit from insights into how to maintain healthier aging processes through targeted interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthier aging and extending longevity.
How similar studies have gone: Previous research has shown promising results in model organisms regarding the role of intertissue communication in aging, suggesting potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Imai, Shin-Ichiro — Washington University
- Study coordinator: Imai, Shin-Ichiro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.