How chromosomes move during mammalian meiosis
Official title: Mechanisms of chromosome motility during mammalian meiosis
Funded at University of Michigan at Ann Arbor · NIH-11563696 · Data updated 2026-11-12
This project studies how chromosomes move in germ cells during meiosis to learn why errors can lead to infertility or miscarriage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $9,180 |
| NIH project number | 3R01HD108809-05S1 |
| Project ID | NIH-11563696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with infertility or recurrent pregnancy loss may benefit from advances in understanding meiosis and chromosome segregation.
✕Less likely to help
Healthy individuals without fertility issues may not directly benefit from this basic science project.
What this research studies
Meiosis is a special cell division in the reproductive cells that creates eggs and sperm. The project focuses on how chromosomes are guided and rearranged at the nuclear envelope, using the SUN1-KASH5 connection to attach chromosomes to motor proteins. Through a combination of approaches, researchers hope to reveal mechanisms behind proper chromosome pairing and crossover, which are essential for healthy fertility. The knowledge gained could improve understanding of human reproductive biology and fertility disorders.
Why it matters
Potential benefit: Better understanding of the causes of infertility and miscarriage, which could lead to improved diagnostics or treatments in the future.
How similar studies have gone: Previous work has connected meiotic chromosome movement to fertility, with ongoing research suggesting these mechanisms are relevant in humans.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Nandakumar, Jayakrishnan — University of Michigan at Ann Arbor
- Study coordinator: Nandakumar, Jayakrishnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.