How chromatin regulation affects brain development and function
Distinct roles of chromatin regulation in transcriptome and genome maintenance in corticogenesis
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10872142
This study is looking at how certain proteins in our DNA help shape the brain and its ability to adapt, which could help us understand conditions like autism and other brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10872142 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin regulation in the development and maintenance of the brain, particularly focusing on how it influences gene expression, DNA replication, and DNA repair. By studying the dynamic control of histone mobility, the research aims to understand how these processes contribute to neural plasticity and the formation of neural circuits. The approach involves examining the mechanisms by which chromatin affects the behavior of neural progenitor cells, which are crucial for brain development. The findings could provide insights into the biological underpinnings of conditions like autism and other brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
Not a fit: Patients with established brain injuries or degenerative brain diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating neurodevelopmental disorders such as autism.
How similar studies have performed: While the role of chromatin in transcription is well-studied, the specific focus on its functions in genome maintenance during neural development is relatively novel and has not been extensively explored in previous research.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KWAN, KENNETH YU-CHUNG — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KWAN, KENNETH YU-CHUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder, Brain Diseases, Brain Disorders