How changes in neuron activity affect gene splicing
Official title: Diverse Patterns of Activity-Dependent Alternative Splicing
Funded at New York University School of Medicine · NIH-10903199 · Data updated 2026-11-12
This study is looking at how the activity of brain cells affects the way certain genes are put together, which is important for keeping our brain functioning well, and it aims to help us understand more about the causes of mental health issues related to these gene changes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,836 |
| NIH project number | 1F31NS137730-01 |
| Project ID | NIH-10903199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neuropsychiatric disorders, particularly those related to autism spectrum disorders.
✕Less likely to help
Patients with conditions unrelated to neuronal activity or splicing mechanisms may not benefit from this research.
What this research studies
This research investigates how the activity of neurons influences the alternative splicing of ion channel genes, which is crucial for maintaining proper neuronal function. By examining different cell types, the study aims to uncover the mechanisms that regulate these splicing patterns in response to varying neuronal activity levels. The approach involves using specific chemical agents to manipulate neuronal activity and observe the resulting changes in gene splicing. This could provide insights into the underlying causes of neuropsychiatric disorders linked to splicing defects.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neuropsychiatric disorders by targeting the mechanisms of alternative splicing.
How similar studies have gone: Previous research has shown promising results in understanding the role of alternative splicing in neuronal function, indicating that this approach has potential for success.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Sun, Yu-Chi — New York University School of Medicine
- Study coordinator: Sun, Yu-Chi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.