How changes in metabolism affect gene expression over time
Control of gene expression by dynamic metabolic oscillations
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11100932
This study is looking at how changes in the way our cells use energy can affect how genes work, especially in relation to aging and how cells respond to stress, which could help us understand more about cell growth and treatment responses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11100932 on ClinicalTrials.gov |
What this research studies
This research investigates how fluctuations in cellular metabolism can influence gene expression, particularly focusing on the dynamic nature of these changes. By examining the role of metabolic oscillations, the study aims to understand how these cycles affect key transcription factors involved in aging and stress responses. Using advanced techniques like live-cell reporters, the researchers will measure how these metabolic changes impact gene expression related to cell growth, differentiation, and response to drugs. The goal is to uncover new insights into how metabolic states can dictate cellular behavior and fate.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related conditions, chronic diseases, or metabolic disorders.
Not a fit: Patients with stable metabolic conditions and no chronic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and improving responses to cancer therapies.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between metabolism and gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALBECK, JOHN G. — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ALBECK, JOHN G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Chronic Disease