How changes in metabolism affect gene expression over time
Control of gene expression by dynamic metabolic oscillations
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10890086
This study is looking at how changes in the way our cells use energy can affect important genes that help with cell growth and stress responses, which could help us understand diseases like cancer and other long-term health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10890086 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between cellular metabolism and gene expression, focusing on how fluctuations in metabolic states can influence the activity of important transcription factors like FOXO3 and TFEB. By examining the dynamic nature of these metabolic changes, the study aims to uncover how they affect gene expression programs that are crucial for cell growth, differentiation, and responses to stress. The researchers will utilize advanced techniques such as live-cell imaging and inducible expression systems to measure the effects of these metabolic oscillations on gene activity. This work could provide insights into the underlying mechanisms of various diseases, including cancer and chronic illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders, chronic diseases, or age-related conditions.
Not a fit: Patients with stable metabolic conditions or those not affected by gene expression-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases by targeting metabolic processes that influence gene expression.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between metabolism and gene expression, indicating that this approach has potential for significant discoveries.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALBECK, JOHN G. — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ALBECK, JOHN G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Chronic Disease