How certain immune cells affect inflammation caused by infections
NKT cell subsets modulate systemic inflammation
This study is looking at how special immune cells called NKT cells affect inflammation during infections, especially when it gets out of control, to find new ways to help people with severe infections feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas El Paso NIH-funded |
| Lab location | 1 site (El Paso, United States) |
| Project ID | NIH-10408738 on NIH RePORTER |
What this research studies
This research investigates how specific immune cells, known as NKT cells, influence the body's inflammatory response during infections. It aims to understand the dual roles these cells play in either promoting or suppressing inflammation, particularly during severe cases known as cytokine storms. By exploring the differences between NKT cell subsets and their distribution in the body, the research seeks to develop immunotherapy strategies that could help control excessive inflammation and improve treatment options for patients with severe infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from severe bacterial infections that trigger excessive inflammation.
Not a fit: Patients with mild infections or those not experiencing significant inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage inflammation during severe infections, potentially saving lives.
How similar studies have performed: Previous studies have shown that targeting immune cell functions can effectively modulate inflammatory responses, suggesting potential success for this approach.
Where this research is happening
El Paso, United States
- University of Texas El Paso — El Paso, United States (Active)
Researchers
- Principal investigator: Spencer, Charles Thomas — University of Texas El Paso
- Study coordinator: Spencer, Charles Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.