How certain harmful substances affect DNA stability and disease development
Official title: Proteotoxic Metabolites in Genome Instability and Disease
Funded at University of Tx Md Anderson Can Ctr · NIH-11020790 · Data updated 2026-11-12
This study looks at how certain harmful substances can damage our DNA and possibly lead to diseases like cancer, helping us understand how lifestyle and genetics might affect our risk of age-related illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $524,400 |
| NIH project number | 1R01CA295874-01 |
| Project ID | NIH-11020790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cancer or age-related diseases, especially those with known exposures to harmful substances.
✕Less likely to help
Patients who do not have any history of cancer or age-related diseases may not receive direct benefits from this research.
What this research studies
This research investigates how various harmful substances, particularly aldehydes, can lead to DNA damage and instability, which may contribute to diseases like cancer. It focuses on understanding how these substances create abnormal protein adducts that interfere with the proper functioning of DNA repair proteins. By studying the effects of these adducts on a key protein involved in DNA repair, the research aims to uncover new mechanisms of genome instability. Patients may benefit from insights gained about how lifestyle choices and genetic factors influence their risk of developing age-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases linked to genome instability, particularly cancer.
How similar studies have gone: Previous research has shown that understanding the effects of DNA damage and repair mechanisms can lead to significant advancements in cancer treatment, suggesting that this approach may also yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Karras, Georgios — University of Tx Md Anderson Can Ctr
- Study coordinator: Karras, Georgios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.