How certain bacteria in our gut help protect against infections from our diet.
Commensal bacterial metabolism of dietary phytate in host defense
This study is looking at how a nutrient called phytate, which is found in some foods, can help good gut bacteria boost our body's ability to fight off intestinal infections, especially in children, by exploring the connection between diet and gut health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11081803 on NIH RePORTER |
What this research studies
This research investigates how a nutrient called phytate, found in certain diets, can be metabolized by beneficial gut bacteria to enhance the body's defense against intestinal infections. By studying both mouse models and human intestines, the researchers aim to understand the relationship between diet, gut microbiota, and immune responses. The goal is to identify dietary strategies that could improve intestinal health and reduce the risk of infections in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may be at risk for intestinal infections.
Not a fit: Patients with established chronic intestinal diseases or those who are not within the age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations that help prevent serious intestinal infections in children.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Hashimoto-Hill, Seika — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Hashimoto-Hill, Seika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.