How certain bacteria affect immune cell function and inflammation
Microbial Disruption of Dendritic Cell Maturation and Function
['FUNDING_R01'] · TUFTS UNIVERSITY BOSTON · NIH-10468732
This study is looking at how a specific type of bacteria in the mouth can change the way our immune cells work, which might help explain why some people develop long-lasting inflammation and conditions like rheumatoid arthritis and heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10468732 on ClinicalTrials.gov |
What this research studies
This research investigates how the oral bacteria Porphyromonas gingivalis alters immune cell function, particularly dendritic cells, which are crucial for initiating immune responses. The study focuses on how modifications in the bacteria's lipid A structure can evade the body's immune detection and contribute to chronic inflammatory diseases like rheumatoid arthritis and cardiovascular disease. By understanding these mechanisms, the research aims to uncover new insights into the relationship between bacterial infections and systemic inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic inflammatory conditions such as rheumatoid arthritis or cardiovascular diseases.
Not a fit: Patients with acute infections or those not affected by chronic inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating chronic inflammatory diseases linked to bacterial infections.
How similar studies have performed: Other research has shown promising results in understanding the role of bacteria in chronic inflammation, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GENCO, CAROLINE A — TUFTS UNIVERSITY BOSTON
- Study coordinator: GENCO, CAROLINE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease