How cells send and process signals
Studies of Global Signal Transduction
This project looks at how a protein called Cdc42 controls cell metabolism and cell-to-cell communication that can influence cancer behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11234273 on NIH RePORTER |
What this research studies
From your perspective, the researchers are studying a protein (Cdc42) that helps cells grow, move, and talk to each other. They use laboratory models, biochemical methods, and molecular mapping to see how Cdc42 changes metabolism and the release of extracellular vesicles that carry signals between cells. The team builds on past discoveries linking Cdc42 to cancer-related processes and aims to map the molecular steps involved. Over time this could point to new markers or targets related to tumor growth and spread.
Who could benefit from this research
Good fit: People with cancers linked to altered cell signaling or those who might donate tumor tissue or blood samples for biomarker research could be relevant to this work.
Not a fit: People without cancer or whose conditions do not involve cell signaling or extracellular vesicle biology are unlikely to see direct benefit from this grant.
Why it matters
Potential benefit: If successful, the work could identify new targets or biomarkers that lead to better cancer treatments or ways to detect aggressive tumors earlier.
How similar studies have performed: Previous studies have shown Cdc42 affects cell behavior and metabolism, and this project builds on those findings to deepen molecular understanding rather than test a new therapy.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Cerione, Richard a. — Cornell University
- Study coordinator: Cerione, Richard a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.