Investigating how cells communicate and regulate growth through signaling pathways
Official title: Studies of Global Signal Transduction
Funded at Cornell University · NIH-11004999 · Data updated 2026-11-12
This study is looking at how a protein called Cdc42 helps cells grow and communicate, which could lead to new treatments for cancer and other conditions when these processes go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $487,425 |
| NIH project number | 5R35GM152206-02 |
| Project ID | NIH-11004999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions related to abnormal cell growth and signaling.
✕Less likely to help
Patients with conditions unrelated to cell signaling or growth regulation may not benefit from this research.
What this research studies
This research focuses on understanding the complex signaling pathways that control cell growth and communication, particularly through a protein called Cdc42. By employing multi-disciplinary approaches, the research aims to uncover how Cdc42 influences various cellular functions and its role in diseases when these pathways are disrupted. Patients may benefit from insights gained about how these signaling processes can be targeted for therapeutic interventions, especially in cancer and other conditions related to cell growth and function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target cell signaling pathways to improve outcomes for patients with cancer and other diseases.
How similar studies have gone: Previous research has shown success in targeting similar signaling pathways for therapeutic purposes, indicating a promising avenue for further exploration.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Cerione, Richard a. — Cornell University
- Study coordinator: Cerione, Richard a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.