How cells communicate in the development of artery disease
RNA-Mediated Inter-Organelle Communication in Atherosclerosis
This study is looking at how certain nutrients and fats can cause inflammation in the arteries, which leads to heart disease, and it aims to find new ways to help prevent or treat this condition, so patients can have better options for their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10630220 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind atherosclerosis, a condition that leads to heart disease by causing inflammation in the arteries. It focuses on how excess nutrients and lipids trigger immune responses and affect cellular communication between organelles. By studying the role of specific proteins and RNA in this process, the research aims to identify new therapeutic targets that could help prevent or treat cardiovascular diseases. Patients may benefit from insights that could lead to innovative treatments for atherosclerosis and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis or related cardiovascular diseases.
Not a fit: Patients with non-cardiovascular diseases or those not affected by atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat atherosclerosis and improve heart health.
How similar studies have performed: Other research has shown promise in understanding organelle communication and its role in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Arditi, Moshe — Cedars-Sinai Medical Center
- Study coordinator: Arditi, Moshe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.