How cell stress changes Salmonella gut infections
The impact of ER stress on Salmonella Typhimurium infections
This project looks at whether stress inside intestinal cells changes how Salmonella causes gut inflammation in people with Salmonella infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11139645 on NIH RePORTER |
What this research studies
Researchers will study how stress in the cell's protein-folding system (the endoplasmic reticulum) and signaling proteins like NOD1 and NOD2 influence Salmonella-driven inflammation in the gut. They plan to use lab-grown intestinal cells and infection models to watch how the unfolded protein response pathways (IRE1α, PERK, ATF6) alter inflammation, cell survival, and bacterial behavior. The team will also examine how genetic differences linked to intestinal disease change these responses. Their work aims to reveal mechanisms that let Salmonella survive in inflamed intestines and point to ways to reduce harmful inflammation.
Who could benefit from this research
Good fit: People who have had recent Salmonella gastroenteritis or who can provide stool samples or intestinal tissue for research would be the most relevant candidates.
Not a fit: People without gut infections or whose symptoms are caused by other non-Salmonella pathogens are unlikely to benefit directly from this research.
Why it matters
Potential benefit: Could point to new ways to reduce intestinal inflammation or help clear Salmonella infections.
How similar studies have performed: Previous lab studies have connected NOD1/NOD2 and the unfolded protein response to inflammation, but applying these links specifically to Salmonella infection is a newer direction.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Keestra-Gounder, Arina Marijke — University of Colorado Denver
- Study coordinator: Keestra-Gounder, Arina Marijke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.