How calcium signaling affects lymphatic muscle cell function
Official title: Regulation of lymphatic muscle cell function by store operated calcium entry signaling
Funded at University of Missouri-Columbia · NIH-10942329 · Data updated 2026-11-12
This study is looking at how calcium signals in lymphatic muscle cells help control fluid movement in the body, especially for people with secondary lymphedema, a condition that causes painful swelling, to find new ways to improve their lymphatic function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $587,042 |
| NIH project number | 1R01HL175083-01 |
| Project ID | NIH-10942329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with secondary lymphedema, particularly those experiencing significant swelling and related complications.
✕Less likely to help
Patients with primary lymphedema or those without any lymphatic dysfunction may not benefit from this research.
What this research studies
This research investigates the role of calcium signaling in lymphatic muscle cells, which are crucial for fluid transport in the body. It focuses on understanding how these cells regulate their function in response to pressure changes, particularly in patients with secondary lymphedema, a condition that causes debilitating swelling. The study will explore the mechanisms behind calcium dynamics and how they influence the contractile activity of lymphatic muscle cells. By identifying these processes, the research aims to uncover potential therapeutic targets for improving lymphatic function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from secondary lymphedema, potentially alleviating their symptoms and improving their quality of life.
How similar studies have gone: While the specific mechanisms of calcium signaling in lymphatic muscle cells are less explored, similar approaches in other areas of signal transduction have shown promise in improving treatment outcomes.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Zawieja, Scott D. — University of Missouri-Columbia
- Study coordinator: Zawieja, Scott D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.