How Brucella bacteria manipulate cell processes to survive
Remodeling of intracellular membrane traffic by Brucella effectors
This study is looking at how Brucella bacteria, which cause brucellosis, manage to survive and grow inside our cells by using special proteins to change how our cells work, and the goal is to find new ways to prevent and treat infections from these bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11049193 on NIH RePORTER |
What this research studies
This research investigates how Brucella bacteria, which cause the disease brucellosis, interact with host cells to enhance their survival and replication. The focus is on understanding the role of specific proteins that these bacteria deliver into host cells, which alter the normal functioning of cellular structures like the Golgi apparatus. By studying these interactions, researchers aim to uncover the mechanisms that allow Brucella to evade the immune response and thrive within host cells. This knowledge could lead to new strategies for preventing and treating infections caused by these pathogens.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals diagnosed with brucellosis or those at high risk of exposure to Brucella bacteria.
Not a fit: Patients with non-infectious diseases or those not exposed to Brucella bacteria are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or vaccines for brucellosis, benefiting patients affected by this disease.
How similar studies have performed: Other research has shown success in understanding bacterial interactions with host cells, making this approach promising but still requiring further exploration.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Celli, Jean a — University of Vermont & St Agric College
- Study coordinator: Celli, Jean a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.