How Brucella bacteria change cells' internal transport systems
Remodeling of intracellular membrane traffic by Brucella effectors
This research aims to show how Brucella bacteria alter the inside of infected cells in ways that could help people and animals with brucellosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11290387 on NIH RePORTER |
What this research studies
You would be hearing about work that looks at how Brucella bacteria send special proteins into host cells to rewire the cell's internal shipping system and make a safe place to grow. Scientists will follow specific bacterial effector proteins (like BspB, BspD, and BspF) and study how they target the Golgi and other cell parts using lab-grown cells, biochemical tests, and high-resolution microscopy. The team combines genetic tools to turn bacterial factors on or off and tracks the changes in cell structure and bacterial replication. These lab findings aim to reveal steps the bacteria use to survive that could later be targeted by treatments or prevention strategies.
Who could benefit from this research
Good fit: People with confirmed brucellosis, those recovering from brucellosis, or individuals with occupational exposure to livestock would be most relevant to this research.
Not a fit: People with infections or health issues unrelated to Brucella are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new targets for drugs or vaccines to prevent or treat brucellosis.
How similar studies have performed: Prior laboratory studies have identified Brucella effector proteins that change host cell trafficking, but translating these findings into treatments is still at an early stage.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Celli, Jean a — University of Vermont & St Agric College
- Study coordinator: Celli, Jean a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.