How blood flow affects cell function and metabolism in blood vessels
Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A Modification
This study looks at how changes in blood flow affect the cells that line our blood vessels and focuses on a special enzyme called METTL3 that helps these cells respond to that flow; by understanding this better, we hope to find new ways to treat heart and blood vessel problems like atherosclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10990943 on NIH RePORTER |
What this research studies
This research investigates how different patterns of blood flow influence the behavior of endothelial cells, which line blood vessels. It focuses on the role of a specific enzyme, METTL3, that modifies RNA molecules in response to blood flow changes. By examining how METTL3 affects glycolysis and inflammation in endothelial cells, the research aims to uncover mechanisms that contribute to conditions like atherosclerosis. Patients may benefit from insights that could lead to new treatments for cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with non-cardiovascular related conditions or those not at risk for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of RNA modifications in cellular processes, indicating potential for success in this area.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Shyy, John Yj — University of California, San Diego
- Study coordinator: Shyy, John Yj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.