How Blood Flow Affects Artery Cells in Heart Disease
Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A Modification
This work explores how different blood flow patterns change artery lining cells, contributing to heart and blood vessel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11123487 on NIH RePORTER |
What this research studies
Our arteries experience different blood flow patterns, some of which can make them more prone to developing blockages. This project looks at how these 'atheroprone' flow patterns cause artery lining cells to become inflamed, multiply too much, and change their energy use. We are focusing on a specific process involving a protein called METTL3, which modifies RNA within these cells, to understand how these changes contribute to the development of atherosclerosis. By understanding these fundamental cellular changes, we hope to uncover new ways to protect our arteries.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with or at risk for atherosclerotic cardiovascular disease, as it seeks to understand the underlying causes of the condition.
Not a fit: Patients seeking immediate new treatments or direct clinical participation will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat atherosclerotic cardiovascular disease by targeting the cellular changes caused by blood flow.
How similar studies have performed: This project builds upon recent preliminary findings from the researchers that suggest a novel role for RNA modification in how artery cells respond to blood flow.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Shyy, John Yj — University of California, San Diego
- Study coordinator: Shyy, John Yj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.