How blood cell mutations contribute to heart disease
Inflammatory contributions of clonal hematopoiesis to cardiovascular disease
['FUNDING_FELLOWSHIP'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10897089
This study is looking at how certain changes in your blood cells, which can happen as you age, might increase your chances of heart disease and leukemia, and it aims to find out how these changes cause inflammation that affects your heart health.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10897089 on ClinicalTrials.gov |
What this research studies
This research investigates a condition known as clonal hematopoiesis of indeterminate potential (CHIP), which involves mutations in blood cells that can lead to an increased risk of cardiovascular disease (CVD) and leukemia. The study aims to understand the inflammatory mechanisms that link these mutations to heart disease, particularly focusing on how certain blood cell populations promote inflammation and atherosclerosis. By examining the role of specific genetic mutations and inflammatory pathways, the research seeks to uncover new insights into the relationship between blood cell changes and cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with clonal hematopoiesis of indeterminate potential (CHIP) who may be at risk for cardiovascular disease.
Not a fit: Patients without clonal hematopoiesis or those who do not have cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients at risk of cardiovascular disease due to blood cell mutations.
How similar studies have performed: Previous research has shown that understanding the genetic and inflammatory mechanisms of blood disorders can lead to significant advancements in treating related cardiovascular conditions.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURNS, SARAH S — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: BURNS, SARAH S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease