How bacteria transport proteins across their membranes
Official title: Protein Transport Across Membrane by Bacterial Pathogens
Funded at University of Missouri-Columbia · NIH-11066531 · Data updated 2026-11-12
This study looks at how certain bacteria, like Legionella pneumophila, move important proteins into our cells, which helps them cause infections and resist antibiotics, and by understanding this process better, we hope to find new ways to fight these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 7, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $388,579 |
| NIH project number | 5R35GM150663-03 |
| Project ID | NIH-11066531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients suffering from infections caused by antibiotic-resistant bacteria would be ideal candidates to benefit from this research.
✕Less likely to help
Patients with infections caused by non-bacterial pathogens or those not affected by antibiotic resistance may not benefit from this research.
What this research studies
This research investigates how bacteria move proteins across their membranes, which is crucial for their ability to cause infections and develop resistance to antibiotics. The focus is on a specific system called the Type IV secretion system (T4SS), which allows bacteria to transport important molecules into host cells. By studying the Dot/Icm T4SS in Legionella pneumophila, the research aims to uncover the mechanisms that enable bacteria to evade the immune system and thrive in hostile environments. This could lead to a better understanding of bacterial infections and antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic-resistant bacterial infections.
How similar studies have gone: Previous research has shown success in understanding bacterial secretion systems, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Durie, Clarissa Lynn — University of Missouri-Columbia
- Study coordinator: Durie, Clarissa Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.