How bacteria respond to stress and stick to surfaces in flowing environments
Official title: Bacterial stress responses and surface adhesion in shear flow
Funded at University of Illinois at Urbana-Champaign · NIH-11132709 · Data updated 2026-11-12
This study looks at how a common germ called Pseudomonas aeruginosa behaves under stress and sticks to surfaces in conditions similar to those in our bodies, which could help us find new ways to treat infections caused by this germ.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | July 4, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $372,497 |
| NIH project number | 5R35GM155443-02 |
| Project ID | NIH-11132709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of infections caused by Pseudomonas aeruginosa, particularly those with compromised immune systems or chronic lung diseases.
✕Less likely to help
Patients who do not have infections caused by Pseudomonas aeruginosa or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how the human pathogen Pseudomonas aeruginosa reacts to stress and adheres to surfaces when exposed to fluid flow, which mimics conditions in the human body. Using advanced microfluidic technology, the study aims to understand the effects of shear forces and hydrogen peroxide on bacterial behavior. By exploring these interactions, the research seeks to uncover fundamental biological processes that could lead to new treatment strategies for bacterial infections. The findings may help in developing better methods to combat infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for preventing and treating infections caused by Pseudomonas aeruginosa.
How similar studies have gone: Previous research has shown promising results in understanding bacterial behavior under flow conditions, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Sanfilippo, Joseph — University of Illinois at Urbana-Champaign
- Study coordinator: Sanfilippo, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.