How B cells can help protect lungs from damage caused by too much oxygen
Protective role of B cells in hyperoxic lung injury
This study is looking at how certain immune cells called B cells can help protect the lungs from damage caused by high oxygen levels, which are often used to treat seriously ill patients with breathing problems, and it hopes to find ways to improve lung health for those patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10984706 on NIH RePORTER |
What this research studies
This research investigates the role of B cells in protecting the lungs from injury caused by high levels of oxygen, which are often necessary for treating critically ill patients with conditions like acute respiratory distress syndrome (ARDS). The study uses animal models to explore how hyperoxia can lead to inflammation and lung damage, particularly focusing on the depletion of B cells. By administering naïve B cells during hyperoxic exposure, the researchers aim to determine if this can reduce inflammation and improve lung function. The findings could lead to new therapeutic strategies for patients suffering from lung injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients with acute respiratory distress syndrome or similar lung injuries requiring oxygen therapy.
Not a fit: Patients who do not have lung injuries or those not requiring oxygen therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help protect lung function in patients receiving high levels of oxygen.
How similar studies have performed: Previous research has shown that B cell therapies can be beneficial in other inflammatory conditions, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hanidziar, Dusan — Massachusetts General Hospital
- Study coordinator: Hanidziar, Dusan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.