How astrocytes influence brain cell connections
Relationship of the Human Astrocyte Matrisome with Synaptic Networks
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10897212
This study is looking at how special brain cells called astrocytes help strengthen connections between nerve cells, using tiny brain models made from human stem cells, to better understand how these connections work and what might help with brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10897212 on ClinicalTrials.gov |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in forming and strengthening connections between neurons. By using advanced bioengineered neural organoids made from human stem cells, the study aims to identify specific proteins produced by mature astrocytes that enhance neuronal synaptic networks. This approach allows for a more accurate understanding of human brain cell interactions compared to traditional methods. The research will analyze how these astrocyte proteins contribute to brain function and may lead to new insights into brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in the biological mechanisms of brain function.
Not a fit: Patients with conditions unrelated to brain function or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain diseases by enhancing our understanding of how brain cells communicate.
How similar studies have performed: Other research has shown promising results in understanding cell interactions in the brain, but this specific approach using bioengineered organoids is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRENCIK, ROBERT CONRAD — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: KRENCIK, ROBERT CONRAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases