How anxiety starts and what predicts it in Fragile X syndrome
Official title: Emergence, stability, and predictors of anxiety in Fragile X syndrome
Funded at University of South Carolina at Columbia · NIH-11090419 · Data updated 2026-11-12
This project looks at how and when anxiety begins and changes over time in children and adolescents with Fragile X syndrome to find early warning signs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 1, 2016 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $706,218 |
| NIH project number | 5R01MH107573-08 |
| Project ID | NIH-11090419 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children and adolescents with a confirmed diagnosis of Fragile X syndrome (especially preschool to middle childhood) and families willing to take part in repeated assessments over time.
✕Less likely to help
People without Fragile X syndrome or those unable/unwilling to participate in repeated visits or evaluations are unlikely to benefit directly from this project.
What this research studies
As a parent or patient, this project follows children with Fragile X over time with regular visits, interviews, and behavioral testing to track anxiety from preschool into middle childhood. The researchers compare kids with Fragile X to children with non-syndromic autism and typically developing children to find what is unique to Fragile X. They use clinical interviews, standardized questionnaires, and observational measures at multiple ages to identify early behaviors that predict later anxiety. Findings from the first funding period showed anxiety appears early and often in Fragile X, and this work extends that follow-up to understand stability and long-term outcomes.
Why it matters
Potential benefit: If successful, this work could help clinicians spot anxiety earlier in people with Fragile X and guide development of targeted screening and early support.
How similar studies have gone: Prior work from the project's initial funding already showed early and common anxiety in Fragile X, so this extension builds on demonstrated findings while adding longer-term follow-up and predictive analysis.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Hogan, Abigail Lee — University of South Carolina at Columbia
- Study coordinator: Hogan, Abigail Lee
Related research
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Understanding anxiety in Fragile X syndrome across childhood
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.